Community-based study to assess the efficacy of DEC plus ALB against DEC alone on bancroftian filarial infection in endemic areas in Tamil Nadu, south India.
Identifieur interne : 007A18 ( Main/Exploration ); précédent : 007A17; suivant : 007A19Community-based study to assess the efficacy of DEC plus ALB against DEC alone on bancroftian filarial infection in endemic areas in Tamil Nadu, south India.
Auteurs : R. Rajendran [Inde] ; I P Sunish ; T R Mani ; A. Munirathinam ; N. Arunachalam ; K. Satyanarayana ; A P DashSource :
- Tropical medicine & international health : TM & IH [ 1360-2276 ] ; 2006.
Descripteurs français
- KwdFr :
- Adolescent, Adulte, Albendazole (usage thérapeutique), Animaux, Antigènes d'helminthe (sang), Antihelminthiques (usage thérapeutique), Association de médicaments, Culex (parasitologie), Diéthylcarbamazine (usage thérapeutique), Enfant, Enfant d'âge préscolaire, Femelle, Filaricides (usage thérapeutique), Filariose lymphatique (traitement médicamenteux), Filariose lymphatique (transmission), Filariose lymphatique (épidémiologie), Humains, Inde (épidémiologie), Maladies endémiques (), Mâle, Observance thérapeutique, Résultat thérapeutique, Santé en zone rurale, Sol (parasitologie), Vecteurs insectes (parasitologie), Études longitudinales.
- MESH :
- parasitologie : Culex, Sol, Vecteurs insectes.
- sang : Antigènes d'helminthe.
- traitement médicamenteux : Filariose lymphatique.
- usage thérapeutique : Albendazole, Antihelminthiques, Diéthylcarbamazine, Filaricides, Filariose lymphatique.
- épidémiologie : Filariose lymphatique, Inde.
- Adolescent, Adulte, Animaux, Association de médicaments, Enfant, Enfant d'âge préscolaire, Femelle, Humains, Maladies endémiques, Mâle, Observance thérapeutique, Résultat thérapeutique, Santé en zone rurale, Études longitudinales.
- Wicri :
- geographic : Inde.
English descriptors
- KwdEn :
- Adolescent, Adult, Albendazole (therapeutic use), Animals, Anthelmintics (therapeutic use), Antigens, Helminth (blood), Child, Child, Preschool, Culex (parasitology), Diethylcarbamazine (therapeutic use), Drug Therapy, Combination, Elephantiasis, Filarial (drug therapy), Elephantiasis, Filarial (epidemiology), Elephantiasis, Filarial (transmission), Endemic Diseases (prevention & control), Female, Filaricides (therapeutic use), Humans, India (epidemiology), Insect Vectors (parasitology), Longitudinal Studies, Male, Patient Compliance, Rural Health, Soil (parasitology), Treatment Outcome.
- MESH :
- chemical , blood : Antigens, Helminth.
- chemical , parasitology : Soil.
- chemical , therapeutic use : Albendazole, Anthelmintics, Diethylcarbamazine, Filaricides.
- geographic , epidemiology : India.
- drug therapy : Elephantiasis, Filarial.
- epidemiology : Elephantiasis, Filarial.
- parasitology : Culex, Insect Vectors.
- prevention & control : Endemic Diseases.
- transmission : Elephantiasis, Filarial.
- Adolescent, Adult, Animals, Child, Child, Preschool, Drug Therapy, Combination, Female, Humans, Longitudinal Studies, Male, Patient Compliance, Rural Health, Treatment Outcome.
Abstract
As part of the Global Programme for Elimination of Lymphatic Filariasis (GPELF), India is implementing mass drug administration (MDA) with annual single dose of diethylcarbamazine (DEC) with and without albendazole (ALB). The impact of MDAs on filarial infections and soil-transmitted helminth (STH) infections was assessed during a 3-year period in two communities, one with DEC + ALB and the other with DEC alone. Prior to each MDA (during 2001, 2002 and 2003), filarial indices (microfilaraemia and antigenaemia) were assessed from blood samples of 450-650 persons aged 2-25 years and STH infections in stool samples (Kato-Katz method) from 325 to 500 children aged 9-10 years. Mosquitoes resting indoors were collected to determine the filarial infection status. The microfilaraemia prevalence decreased significantly (P < 0.05) in both arms, with the highest decline in the DEC + ALB arm (72%vs. 51%). Decline in micrefilaria intensity was also higher in the DEC + ALB arm (81.4%vs. 48.5%). In this arm alone, the antigenaemia prevalence was reduced significantly (62%; P < 0.001). The reduction in STH prevalence was lower in the DEC alone arm (6.5%; NS) than in the DEC + ALB arm (70.9%; P < 0.001). Also, the egg reduction in DEC alone arm was only half that of DEC + ALB arm (49%vs. 97%). Our community-based follow-up study showed higher and sustained benefits with regard to filarial and STH infections for the two-drug arm over the DEC alone arm. The trends suggest that at least 10 MDAs may be necessary to achieve the goal of elimination.
DOI: 10.1111/j.1365-3156.2006.01625.x
PubMed: 16772007
Affiliations:
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Le document en format XML
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Rajendran</name><affiliation wicri:level="1"><nlm:affiliation>Centre for Research in Medical Entomology, Madurai, India. crmeicmr@icmr.org.in</nlm:affiliation><country xml:lang="fr">Inde</country><wicri:regionArea>Centre for Research in Medical Entomology, Madurai</wicri:regionArea><wicri:noRegion>Madurai</wicri:noRegion></affiliation></author><author><name sortKey="Sunish, I P" sort="Sunish, I P" uniqKey="Sunish I" first="I P" last="Sunish">I P Sunish</name></author><author><name sortKey="Mani, T R" sort="Mani, T R" uniqKey="Mani T" first="T R" last="Mani">T R Mani</name></author><author><name sortKey="Munirathinam, A" sort="Munirathinam, A" uniqKey="Munirathinam A" first="A" last="Munirathinam">A. Munirathinam</name></author><author><name sortKey="Arunachalam, N" sort="Arunachalam, N" uniqKey="Arunachalam N" first="N" last="Arunachalam">N. 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control)</term><term>Female</term><term>Filaricides (therapeutic use)</term><term>Humans</term><term>India (epidemiology)</term><term>Insect Vectors (parasitology)</term><term>Longitudinal Studies</term><term>Male</term><term>Patient Compliance</term><term>Rural Health</term><term>Soil (parasitology)</term><term>Treatment Outcome</term></keywords><keywords scheme="KwdFr" xml:lang="fr"><term>Adolescent</term><term>Adulte</term><term>Albendazole (usage thérapeutique)</term><term>Animaux</term><term>Antigènes d'helminthe (sang)</term><term>Antihelminthiques (usage thérapeutique)</term><term>Association de médicaments</term><term>Culex (parasitologie)</term><term>Diéthylcarbamazine (usage thérapeutique)</term><term>Enfant</term><term>Enfant d'âge préscolaire</term><term>Femelle</term><term>Filaricides (usage thérapeutique)</term><term>Filariose lymphatique (traitement médicamenteux)</term><term>Filariose lymphatique (transmission)</term><term>Filariose lymphatique 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xml:lang="fr"><term>Albendazole</term><term>Antihelminthiques</term><term>Diéthylcarbamazine</term><term>Filaricides</term><term>Filariose lymphatique</term></keywords><keywords scheme="MESH" qualifier="épidémiologie" xml:lang="fr"><term>Filariose lymphatique</term><term>Inde</term></keywords><keywords scheme="MESH" xml:lang="en"><term>Adolescent</term><term>Adult</term><term>Animals</term><term>Child</term><term>Child, Preschool</term><term>Drug Therapy, Combination</term><term>Female</term><term>Humans</term><term>Longitudinal Studies</term><term>Male</term><term>Patient Compliance</term><term>Rural Health</term><term>Treatment Outcome</term></keywords><keywords scheme="MESH" xml:lang="fr"><term>Adolescent</term><term>Adulte</term><term>Animaux</term><term>Association de médicaments</term><term>Enfant</term><term>Enfant d'âge préscolaire</term><term>Femelle</term><term>Humains</term><term>Maladies endémiques</term><term>Mâle</term><term>Observance thérapeutique</term><term>Résultat thérapeutique</term><term>Santé en zone rurale</term><term>Études longitudinales</term></keywords><keywords scheme="Wicri" type="geographic" xml:lang="fr"><term>Inde</term></keywords></textClass></profileDesc></teiHeader><front><div type="abstract" xml:lang="en">As part of the Global Programme for Elimination of Lymphatic Filariasis (GPELF), India is implementing mass drug administration (MDA) with annual single dose of diethylcarbamazine (DEC) with and without albendazole (ALB). The impact of MDAs on filarial infections and soil-transmitted helminth (STH) infections was assessed during a 3-year period in two communities, one with DEC + ALB and the other with DEC alone. Prior to each MDA (during 2001, 2002 and 2003), filarial indices (microfilaraemia and antigenaemia) were assessed from blood samples of 450-650 persons aged 2-25 years and STH infections in stool samples (Kato-Katz method) from 325 to 500 children aged 9-10 years. Mosquitoes resting indoors were collected to determine the filarial infection status. The microfilaraemia prevalence decreased significantly (P < 0.05) in both arms, with the highest decline in the DEC + ALB arm (72%vs. 51%). Decline in micrefilaria intensity was also higher in the DEC + ALB arm (81.4%vs. 48.5%). In this arm alone, the antigenaemia prevalence was reduced significantly (62%; P < 0.001). The reduction in STH prevalence was lower in the DEC alone arm (6.5%; NS) than in the DEC + ALB arm (70.9%; P < 0.001). Also, the egg reduction in DEC alone arm was only half that of DEC + ALB arm (49%vs. 97%). Our community-based follow-up study showed higher and sustained benefits with regard to filarial and STH infections for the two-drug arm over the DEC alone arm. The trends suggest that at least 10 MDAs may be necessary to achieve the goal of elimination.</div></front></TEI><affiliations><list><country><li>Inde</li></country></list><tree><noCountry><name sortKey="Arunachalam, N" sort="Arunachalam, N" uniqKey="Arunachalam N" first="N" last="Arunachalam">N. Arunachalam</name><name sortKey="Dash, A P" sort="Dash, A P" uniqKey="Dash A" first="A P" last="Dash">A P Dash</name><name sortKey="Mani, T R" sort="Mani, T R" uniqKey="Mani T" first="T R" last="Mani">T R Mani</name><name sortKey="Munirathinam, A" sort="Munirathinam, A" uniqKey="Munirathinam A" first="A" last="Munirathinam">A. Munirathinam</name><name sortKey="Satyanarayana, K" sort="Satyanarayana, K" uniqKey="Satyanarayana K" first="K" last="Satyanarayana">K. Satyanarayana</name><name sortKey="Sunish, I P" sort="Sunish, I P" uniqKey="Sunish I" first="I P" last="Sunish">I P Sunish</name></noCountry><country name="Inde"><noRegion><name sortKey="Rajendran, R" sort="Rajendran, R" uniqKey="Rajendran R" first="R" last="Rajendran">R. Rajendran</name></noRegion></country></tree></affiliations></record>Pour manipuler ce document sous Unix (Dilib)
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